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目的观察维生素D对2型糖尿病患者合并呼吸道感染患者的临床疗效。方法 60例2型糖尿病合并呼吸道感染患者随机分为对照组30例和试验组30例。2组均常规抗感染及胰岛素强化治疗,对照组口服自制安慰剂胶丸1丸,每日1次;试验组口服骨化三醇胶丸1丸,每日1次,均连续服用24周。比较2组患者治疗前和治疗后4,24周血清葡萄糖、血清钙、25羟维生素D3[25(OH)D_3]及免疫因子分化簇3(CD_3)、分化簇4(CD_4)、补体C3、免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)水平。结果治疗后,2组患者血糖水平显著低于治疗前(P<0.05),试验组25(OH)D3水平升高,且高于对照组(P<0.05);治疗后,2组患者CD4水平升高(P<0.05),且试验组高于对照组(P<0.05);治疗后,2组患者免疫球蛋白A水平下降,免疫球蛋白G、C3水平上升(P<0.05),且试验组免疫球蛋白A水平较低,免疫球蛋白G、C3水平较高(P<0.05)。结论口服维生素D对于2型糖尿病合并呼吸道感染患者能够显著提高补体水平。
Objective To observe the clinical effect of vitamin D on type 2 diabetes mellitus patients with respiratory tract infection. Methods Sixty patients with type 2 diabetes mellitus and respiratory tract infection were randomly divided into control group (30 cases) and experimental group (30 cases). The two groups were routine anti-infective and insulin-intensive treatment, the control group of oral self-made placebo capsules 1 pill, 1 day; test group oral calcitriol pellets 1 pill, once daily, were taken continuously for 24 weeks. The levels of serum glucose, serum calcium, 25-hydroxyvitamin D3 [25 (OH) D_3], immune differentiation cluster 3 (CD_3), differentiation cluster 4 (CD_4), complement C3, Immunoglobulin A (Ig A), Immunoglobulin G (Ig G) levels. Results After treatment, the blood glucose levels in two groups were significantly lower than those before treatment (P <0.05), and the levels of 25 (OH) D3 in the experimental group were significantly higher than those in the control group (P <0.05) (P <0.05), and the experimental group was higher than that of the control group (P <0.05). After treatment, the immunoglobulin A level decreased and the immunoglobulin G and C3 levels increased in the two groups (P <0.05) Group immunoglobulin A low level, immunoglobulin G, C3 levels were higher (P <0.05). Conclusion Oral vitamin D can significantly improve the level of complement in type 2 diabetic patients with respiratory tract infection.