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目的探讨不同药物在治疗胃体部及十二指肠溃疡时的治疗效果,指导临床合理用药。方法 180例胃体部及十二指肠溃疡患者,根据患者自主意愿分为甲、乙、丙组,各60例。甲组采用雷尼替丁进行治疗,乙组采用奥美拉唑进行治疗,丙组采用泮托拉唑进行治疗,比较三组患者胃体部及十二指肠溃疡的恢复状况以及不良反应发生率。结果甲组总有效率为83.3%、乙组为91.7%、丙组为95.0%,甲组不良反应发生率为18.3%、乙组为10.0%、丙组为5.0%,丙组总有效率、不良反应发生率略优于乙组(P>0.05),但明显优于甲组(P<0.05)。结论服用泮托拉唑的患者疗效明显优于服用传统药物雷尼替丁,略优于奥美拉唑,不良症状少,应在临床应用上逐渐推广。
Objective To investigate the therapeutic effect of different drugs in the treatment of gastric body and duodenal ulcer, and to guide clinical rational drug use. Methods 180 cases of gastric body and duodenal ulcer patients, divided into A, B, C group, 60 cases each according to their own wishes. Group A was treated with ranitidine, group B was treated with omeprazole, group C was treated with pantoprazole, and the recovery status of gastric body and duodenal ulcer in the three groups were compared with those of adverse reactions rate. Results The total effective rate in group A was 83.3%, in group B 91.7%, in group C 95.0%, in group A 18.3%, in group B 10.0%, in group C 5.0%, in group C the total effective rate was 83.3% The incidence of adverse reactions was slightly better than that of group B (P> 0.05), but significantly better than that of group A (P <0.05). Conclusions Patients taking pantoprazole are superior to ranitidine in taking traditional medicine, slightly better than omeprazole, with few adverse symptoms. They should be gradually popularized in clinical application.