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Behcet病是一种慢性进行性疾病,可累及包括眼在内的多个系统。本病病因不明,但有人报道,其发病机理与多种免疫调节异常有关。自然杀伤细胞(NKC)是一种天然存在的对肿瘤的毒性细胞,它可引起很多与干扰素和巨噬细胞有密切关系的免疫现象。有人报道,在慢性病如系统性红斑狼疮、多发性硬化和眼干燥综合征中,NK细胞的活性降低。作者对符合Behcet病诊断标准的20例患者进行了末梢血淋巴细胞的NK细胞活性检查.用标有~(51)Cr的K_(562)与分离出来的效应细胞混合培育4小时,然后测定其释出的放射活性。测得患者组NK细胞活性平均为
Behcet’s disease is a chronic progressive disease that can involve multiple systems, including the eye. The etiology of this disease is unknown, but it was reported that its pathogenesis and a variety of immune regulation abnormalities. Natural killer cell (NKC) is a naturally occurring toxic tumor cells, it can cause a lot of interferon and macrophages are closely related to the immune phenomenon. It has been reported that in chronic diseases such as systemic lupus erythematosus, multiple sclerosis and dry eye syndrome, NK cell activity is reduced. The authors examined the NK cell activity of peripheral blood lymphocytes in 20 patients who met the criteria for Behcet’s disease and were incubated with the isolated effector cells for 48 hours with K_ (562) labeled with ~ (51) Cr and then assayed Released radioactivity. Measured in patients with NK cell activity average of