恶性肿瘤呈高代谢状态,仅通过输注热量和蛋白质并不能有效地减轻机体的分解状态。而生长激素在综合治疗中,能改善病人的营养不良和负氮平衡,提高疗效和耐受性。其作用的关键就是与生长激素受体(GHR)结合。现就GHR的表达和功能以及受体后信号对目的基因的调节、自我调节作一综述。 Malignant tumors showed a high metabolic state, only by infusion of heat and protein and can not effectively reduce the body’s decomposition status. Growth hormone in the comprehensive treatment, can improve patients with malnutrition and negative nitrogen balance, improve efficacy and tolerance. The key to its role is binding to the growth hormone receptor (GHR). Now on the expression and function of GHR as well as the regulation of the target gene after receptor signal, self-regulation are reviewed.