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对1230例具有胃部不适患者的胃粘膜活检及4例术后良恶性疾病大胃标本的胃粘膜按要求取材,进行了HE及Warthin-Starry染色检查,其中13例进行了透射电镜研究。幽门弯曲菌(Campylobacter pyloridis以下简称CP)阳性率为78.2％,发现此菌的感染与慢性胃炎尤其是慢性活动性胃炎、消化性溃疡密切相关。探讨了CP感染与胃癌及癌前病变的关系,同时也探讨了甘肃省胃癌高发区CP对胃癌发生的影响。通过电镜观察到CP菌体位于粘膜上皮不规则的微绒毛之间,细菌大多聚集于微绒毛之表面。
Gastric mucosal biopsies from 1230 patients with stomach discomfort and gastric mucosa from 4 patients with benign and malignant diseases were collected on request. HE and Warthin-Starry staining were performed, of which 13 were examined by transmission electron microscopy. The positive rate of Campylobacter pyloridis (CP) was 78.2%. It was found that the infection of this bacterium was closely related to chronic gastritis, especially chronic active gastritis and peptic ulcer. The relationship between CP infection and gastric cancer and precancerous lesions was also discussed. At the same time, the effect of CP on GC in Gansu province was also discussed. It was observed by electron microscopy that the bacterial cells of the CP were located between the irregular microvilli of mucosal epithelium, and the bacteria mostly clustered on the surface of the microvilli.