最近,在本实验室(哈佛大学化学系)合成衣霉素的研究中,需要一种关键中间体——硝基半乳糖衍生物1.尝试了许多已知的合成方法,都失败了。特别是,用Kornblum亚硝酸银取代的方法,从相应的6-碘半乳糖来合成,似乎是最合适的,但在各种条件下都检测不出1。这种结果使我们考虑从卤化物和磺酸盐来合成硝基化合物。 Recently, in our lab (Department of Chemistry, Harvard University) for the synthesis of tunicamycin, a key intermediate, nitro galactose derivative, was required.1 Many known synthetic methods were tried and failed. In particular, the method of substitution with Kornblum silver nitrite appears to be most suitable for synthesis from the corresponding 6-iodo galactose, but 1 is not detectable under all conditions. This result led us to consider the synthesis of nitro compounds from halides and sulfonates.