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目的探讨环氧化酶(COX-2)和血管内皮生长因子-C(VEGF-C)在宫颈癌组织、宫颈上皮内瘤变组织和正常宫颈组织中的表达及意义。方法采用免疫组织化学SP法检测50例宫颈癌组织,50例宫颈上皮内瘤变组织及50例正常宫颈组织中COX-2和VEGF-C的表达,从而研究两者在宫颈病变组织中的表达情况及相关性。结果 COX-2在宫颈癌组织、宫颈上皮内瘤变组织和正常宫颈组织中的阳性率分别为90.00%,54.00%和16.00%,且在宫颈癌组织中的表达与其他两组比较差异具有统计学意义(χ~2=27.682,P<0.05),在不同级别宫颈上皮内瘤变组织中表达差异具有统计学意义(χ~2=18.313,P<0.05);VEGF-C在宫颈癌组织、宫颈上皮内瘤变组织和正常宫颈组织中的阳性率分别为24.00%,52.00%和92.00%,且在宫颈癌组织中的表达与其他两组比较差异具有统计学意义(χ~2=25.585,P<0.05),在不同级别宫颈上皮内瘤变组织中表达差异具有统计学意义(χ~2=17.133,P<0.05);经Spearson相关性分析,两者在宫颈癌组织中的发生、发展过程中存在负相关(r=-0.425,P<0.05)。结论 COX-2和VEGF-C在宫颈癌的发生、发展中起了一定的作用,且两者共同参与了宫颈癌的发生和发展。
Objective To investigate the expression and significance of cyclooxygenase (COX-2) and vascular endothelial growth factor-C (VEGF-C) in cervical cancer, cervical intraepithelial neoplasia and normal cervical tissue. Methods The expressions of COX-2 and VEGF-C in 50 cases of cervical cancer, 50 cases of cervical intraepithelial neoplasia and 50 cases of normal cervical tissue were detected by immunohistochemical SP method to study the expression of COX-2 and VEGF-C in cervical lesions Situation and relevance. Results The positive rates of COX-2 in cervical cancer, cervical intraepithelial neoplasia and normal cervical tissue were 90.00%, 54.00% and 16.00%, respectively. The positive rates of COX-2 in cervical cancer were statistically different from those in other two groups (Χ ~ 2 = 27.682, P <0.05). The expression of VEGF-C was significantly different in different grades of cervical intraepithelial neoplasia (χ ~ 2 = 18.313, The positive rates in cervical intraepithelial neoplasia and normal cervical tissues were 24.00%, 52.00% and 92.00%, respectively. The positive rates in cervical intraepithelial neoplasia and normal cervical tissues were statistically different from those in other two groups (χ ~ 2 = 25.585, (P <0.05). There was significant difference in the expression of different grades of cervical intraepithelial neoplasia (χ ~ 2 = 17.133, P <0.05). According to the Spearson correlation analysis, the occurrence and development of the two in cervical cancer There was a negative correlation (r = -0.425, P <0.05). Conclusions COX-2 and VEGF-C play a role in the occurrence and development of cervical cancer, and they both participate in the occurrence and development of cervical cancer.