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目的探讨谷胱甘肽-S-转移酶M1和T1与低出生体重儿易感性的关系。方法按照纳入排除标准全面检索Pub Med、Web of Science、EMBASE、中国生物医学文献数据库和CNKI等数据库相关文献,收集谷胱甘肽-S-转移酶M1和T1与低出生体重儿的关联性研究,应用Revman5.1及Stata11.0软件进行合并效应值估计、发表偏倚的检验和敏感性分析。结果共纳入符合条件的文献10篇,母亲携带GSTM1null基因型新生儿低出生体重发病风险增加(OR=1.19,95%CI:1.04~1.38,P=0.01),新生儿GSTM1基因多态性与低出生体重的关联性差异无统计学意义(OR=0.85,95%CI:0.55~1.30,P=0.45);母亲GSTT1基因多态性与低出生体重的关联性差异无统计学意义(OR=1.15,95%CI:0.98~1.35,P=0.09),新生儿携带GSTT1null基因型低出生体重的发病风险增加(OR=2.50,95%CI:1.12~5.59,P=0.03)。结论母亲GSTM1null基因型和新生儿GSTT1null基因型是新生儿低出生体重发生的危险因素。
Objective To investigate the relationship between glutathione S-transferase M1 and T1 and susceptibility to low birth weight infants. Methods According to the inclusion criteria, a comprehensive search of Pub Med, Web of Science, EMBASE, Chinese Biomedical Literature Database and CNKI database was performed to investigate the association between glutathione S-transferase M1 and T1 and low birth weight infants , The use of Revman5.1 and Stata11.0 software merger effect estimation, publication bias test and sensitivity analysis. Results A total of 10 eligible articles were included. The risk of low birth weight was increased in mothers with GSTM1 null genotype (OR = 1.19, 95% CI: 1.04-1.38, P = 0.01). Neonatal GSTM1 gene polymorphism was associated with low (OR = 0.85, 95% CI: 0.55-1.30, P = 0.45). There was no significant difference in the association between maternal GSTT1 gene polymorphism and low birth weight (OR = 1.15 , 95% CI: 0.98-1.35, P = 0.09). The incidence of low birth weight in neonates with GSTT1null genotype increased (OR = 2.50,95% CI: 1.12-5.59, P = 0.03). Conclusion The genotypes of GSTM1null and GSTT1null in neonates are risk factors of low birth weight in neonates.