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目的探讨白细胞介素6(IL-6)、白细胞介素8(IL-8)和C反应蛋白(CRP)在细菌性肺炎患者中的水平及其临床意义。方法以120例细菌性肺炎患者为试验组,以80例健康人作为对照组;分别抽取对照组及试验组治疗前后的空腹静脉血进行IL-6、IL-8和CRP的检测。结果细菌性肺炎患者中的IL-6及IL-8及CRP均明显高于对照组,差异具有统计学意义(P<0.001)。同时与治疗前相比,细菌性肺炎组患者治疗后IL-6及IL-8及CRP水平明显降低,差异具有统计学意义(P<0.001),而与对照组相比差异无统计学意义(P>0.05)。结论 IL-6及IL-8及CRP在细胞性肺炎患者中的检测有助于患者病情的早期诊断及疗效评估。
Objective To investigate the levels and clinical significance of interleukin 6 (IL-6), interleukin 8 (IL-8) and C-reactive protein (CRP) in patients with bacterial pneumonia. Methods 120 patients with bacterial pneumonia were selected as experimental group and 80 healthy individuals as control group. The levels of IL-6, IL-8 and CRP in control group and experimental group were measured before and after treatment. Results The levels of IL-6, IL-8 and CRP in patients with bacterial pneumonia were significantly higher than those in control group (P <0.001). At the same time, the levels of IL-6, IL-8 and CRP in patients with bacterial pneumonia were significantly lower than those before treatment, the difference was statistically significant (P <0.001), while there was no significant difference compared with the control group P> 0.05). Conclusion The detection of IL-6, IL-8 and CRP in patients with cell pneumonia is helpful for the early diagnosis and evaluation of the patients’ condition.