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目的 探讨p53蛋白表达在大肠癌进展中的意义。方法 对 42例大肠癌组织采用免疫组织化学方法及标准核分裂计数法分别测定 p53蛋白表达情况及核分裂指数 (MI)。 结果 42例大肠癌组织中 p53蛋白阳性率为 50 .0 % ,p53蛋白表达与MI及大肠癌浸润深度呈明显正相关 ,而与组织学分级、淋巴结转移等无密切相关。结论 p53蛋白表达对大肠癌的进展具有重要影响 ,可与MI结合作为大肠癌的预后指标。
Objective To investigate the significance of p53 protein expression in the progression of colorectal cancer. Methods The expression of p53 protein and mitotic index (MI) in 42 cases of colorectal carcinoma were detected by immunohistochemical method and standard mitotic count method respectively. Results The positive rate of p53 protein in 42 cases of colorectal carcinoma was 50.0%. There was a positive correlation between the expression of p53 protein and the infiltration depth of MI and colorectal carcinoma, but not with the histological grade and lymph node metastasis. Conclusion The expression of p53 protein has an important effect on the progression of colorectal cancer, and may be used as a prognostic indicator of colorectal cancer.