本文报道7例同时应用速尿和庆大霉素的临床观察。速尿给药后能使肾小球滤过率显著下降。正常志愿受试者静注速尿后,肾小球滤过率减少30～40%,庆大霉素血浆清除率减少约24%。该7例被观察研究的病人的肾功能均正常,其血清肌酸酐值(±标准差)平均为80±9.4μmole/L,血清尿素平均为6.6±2.5mmole/L,血红蛋白平均值为12.1±0.5g/dl,平均尿流量为2.6±0.9ml/分。静脉注射速尿40mg,一小 This article reports 7 cases of simultaneous application of furosemide and gentamicin clinical observation. After furosemide administration glomerular filtration rate can significantly decreased. Normal volunteers after intravenous furosemide, glomerular filtration rate decreased 30 ~ 40%, gentamicin plasma clearance rate decreased by about 24%. The 7 observed patients had normal renal function with an average serum creatinine (± SD) of 80 ± 9.4 μmole / L, an average serum urea of ​​6.6 ± 2.5 mmole / L and an average hemoglobin of 12.1 ± 0.5g / dl, average urine flow of 2.6 ± 0.9ml / min. Intravenous furosemide 40mg, a small