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目的：探讨654-2对创伤性低血容量性休克所致的多脏器功能不全综合征（MODS）的预防作用。方法：在创伤后不同时间应用654-2．并观察其MODS的发生率及预后。结果：创伤后第7、10天，早期应用654－2组其MODS发生率及死亡率显著低于后期应用654－2组及未应用组；后两组之间MODS发生率及死亡率无显著差别。创伤后第15天，654－2早期应用组、后期应用组及未应用组MODS发生率及死亡率无显著差别。提示：创伤早期应用654-2对预防创伤性MODS及延迟其发生有一定作用，但不能阻断其病理进行及最终发生率。创伤后期应用654-2对创伤性MODS的预防作用差。
Objective: To investigate the preventive effect of 654-2 on multiple organ dysfunction syndrome (MODS) caused by traumatic hypovolemic shock. Methods: 654-2 was applied at different times after trauma. And observe the incidence and prognosis of MODS. Results: The morbidity and mortality of MODS in the early stage of application of the 654-2 group were significantly lower than those of the 654-2 group and the non-applied group at the 7th and 10th days after trauma. The incidence and mortality of MODS in the latter two groups were not significant difference. On the 15th day after trauma, there was no significant difference in the incidence and mortality of MODS between the early application group, the late application group and the non-application group. Tip: early application of trauma 654-2 on traumatic MODS and delay the occurrence of a certain role, but can not block the pathological progress and the final incidence. Post-traumatic application of 654-2 has a poor preventive effect on traumatic MODS.