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[目的]探讨康复新液对幽门螺杆菌(Hp)阳性胃炎患者胃黏膜改善情况、症状改善情况及临床疗效。[方法]选取2014年5月~2016年12月在我院接受治疗Hp阳性胃炎的患者160例进行分析。将160例患者随机分成观察组(80例)和对照组(80例),对照组给予常规三联疗法治疗,观察组在常规三联疗法基础上加服康复新液进行治疗。观察并比较2组患者治疗前后临床疗效、症状(恶心、反酸、嗳气、上腹疼痛)发生率及炎性因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及C-反应蛋白(CRP)]水平。[结果]观察组治疗后总有效率为87.50%高于,对照组,差异有统计学意义(P<0.05)。2组治疗前症状发生率比较,差异无统计学意义;2组治疗后症状发生率比治疗前明显降低(P<0.05);观察组治疗后症状发生率降低幅度大于对照组(P<0.05)。2组治疗前TNF-α、IL-6及CRP水平比较,差异无统计学意义;2组治疗后TNF-α、IL-6及CRP水平较治疗前明显下降(P<0.05);观察组治疗后TNF-α、IL-6及CRP水平下降幅度大于对照组(P<0.05)。[结论]康复新液治疗Hp阳性胃炎可提高临床疗效、降低症状发生率和炎性因子水平。
[Objective] To investigate the effect of Kangfuxin on gastric mucosa in patients with Helicobacter pylori (Hp) -positive gastritis, the improvement of symptoms and clinical efficacy. [Methods] From May 2014 to December 2016 in our hospital for treatment of Hp-positive gastritis in 160 patients were analyzed. 160 patients were randomly divided into observation group (80 cases) and control group (80 cases). The control group was treated with conventional triple therapy. The observation group was treated with rehabilitation new liquid on the basis of conventional triple therapy. The incidences of symptoms and signs (nausea, acid reflux, belching, upper abdominal pain) and the incidence of inflammatory cytokines including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were observed and compared between the two groups before and after treatment And C-reactive protein (CRP)] levels. [Results] The total effective rate of observation group after treatment was 87.50% higher than that of the control group, the difference was statistically significant (P <0.05). There was no significant difference between the two groups in the incidence of symptoms before treatment; the incidence of symptoms in the two groups was significantly lower than that before treatment (P <0.05); the incidence of symptoms in the observation group decreased more significantly than that in the control group (P <0.05) . The levels of TNF-α, IL-6 and CRP in the two groups before treatment were not significantly different. The levels of TNF-α, IL-6 and CRP in the two groups were significantly decreased after treatment (P <0.05) The decrease of TNF-α, IL-6 and CRP levels was greater than that of the control group (P <0.05). [Conclusion] Kangfuxinye treatment of Hp-positive gastritis can improve the clinical efficacy, reduce the incidence of symptoms and inflammatory cytokines.