用放射免疫分析方法测定了32例小儿肺炎极期和恢复期血浆心钠素(ANP)浓度。结果显示:极期心钠素水平明显增加(2456.7±1055.68 pg/ml),与正常对照组(768.92±207.34 Pg/ml)及恢复期(903.37±314.65 pg/ml)比较,差异有显著性意义(P<0.01)。其中7例肺炎合并心衰者其值更高,恢复期均接近正常水平。并初步探讨了小儿肺炎血浆心钠素升高的发病机理,提示测定血浆心钠素水平对诊断肺炎心衰有一定的临床价值,对其疗效观察有一定的指导意义。 Radioimmunoassay was used to determine plasma atrial natriuretic peptide (ANP) concentrations in 32 children with pneumonia at both polar and convalescent stages. The results showed that the level of atrial natriuretic peptide increased significantly (2456.7 ± 1055.68 pg / ml) during the period, which was significantly different from the normal control group (768.92 ± 207.34 Pg / ml) and the recovery period (903.37 ± 314.65 pg / ml) (P <0.01). Among them, seven cases of pneumonia complicated with heart failure had higher values ​​and recovery periods were close to normal levels. And initially explored the pathogenesis of plasma atrial natriuretic peptide in children with pneumonia, suggesting that the determination of plasma atrial natriuretic peptide has some clinical value in the diagnosis of pneumonia with heart failure, and it is of guiding significance for its curative effect observation.