８０年代首次将喹诺酮类用于全身感染的治疗，几年后即用于眼科感染，尤其是联合传统的外科疗法治疗内眼炎。最近开发的０．３％环丙沙星（ＣＰＦＸ）、氧氟沙星（ＯＦＸ）和诺氟沙星（ＮＦＸ）滴眼液临床证实治疗眼科感染有效且耐受良好。喹诺酮类的眼内穿透性研究大部分在非 For the first time in the 1980s, quinolones were used for the treatment of systemic infections and were used for ophthalmic infections only a few years later, especially in the treatment of endophthalmitis with traditional surgical therapies. Recently developed 0.3% ciprofloxacin (CPFX), ofloxacin (OFX) and norfloxacin (NFX) eye drops clinically proven to be effective and well tolerated for ophthalmic infections. Quinolones most of the intraocular penetrating research in Africa