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用苯巴比妥与β-环糊精制成复合栓剂直肠给药,可提高苯巴比妥的吸收。复合物的制备:苯巴比妥和β-环糊精(1:1分子比例)溶于热水,过滤得复合物。平均粒度为17μm。栓剂的制备:聚乙二醇栓系用聚乙二醇-1000和4000,以3:1重量比混合熔化,将药物或复合物混悬于熔化的基质中,注入制栓模。每栓含50mg 药物。作者分别测定比较了复合物、苯巴比妥粉、复合栓、苯巴比妥栓在盐水中的溶解速率;复合栓和苯巴
With phenobarbital and β-cyclodextrin compound suppositories rectal administration, can improve the absorption of phenobarbital. Complex Preparation: Phenobarbital and β-cyclodextrin (1: 1 ratio of molecules) dissolved in hot water, filtered to obtain a complex. The average particle size is 17 μm. Suppository Preparation: Polyethylene glycol tetrapheres polyethylene glycol-1000 and 4000, melted in a 3: 1 ratio by weight, suspending the drug or the complex in a melted matrix, and pouring into a tumble mold. Each suppository contains 50 mg of drug. The authors measured and compared the dissolution rate of compound, phenobarbital powder, compound suppository and phenobarbital in saline solution respectively. The combination suppository and phenobarbital