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用健康昆明种小鼠，以11．8和2．4g／（kg·d）抗氟灵连续灌胃5次，每次间隔24小时，分别用0．04g／（kg·d）环磷酰胺和0．002g／（kg·d）丝裂霉素C为阳性对照，1ml／（kg·d）蒸馏水为阴性对照进行微核和精原及精母细胞染色体畸变试验，结果实验组小鼠骨髓嗜多染红细胞微核发生率明显低于阳性对照组（P＜0．01），高于阴性对照组（P＞0．05），睾丸精原与精母细胞染色体畸变率比阳性对照组低（P＜0．01），比阴性对照组高（P＞0．05）。抗氟灵无明显致突变效应。
Healthy Kunming mice were treated with antifluralin at 11.8 and 2.4 g / (kg · d) for 5 consecutive gavages. Each time interval was 24 hours, mice were treated with 0.04 g / (kg · d) cyclophosphamide And 0.002g / (kg · d) of mitomycin C as positive control, 1ml / (kg · d) distilled water as negative control for micronuclei and spermatogonia and spermatocyte chromosomal aberration test results in the experimental group of mouse bone marrow The incidence of micronuclei in polychromatic erythrocytes was significantly lower than that in the positive control group (P <0.01), higher than that in the negative control group (P> 0.05). The chromosome aberration rate of spermatogonia and spermatocytes in testis was lower than that in the positive control group (P <0.01), higher than the negative control group (P> 0.05). Fluoride no obvious mutagenic effect.