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氟化铅是一种由不同粒径白色粉末制成的半透明片剂。实验用成年大鼠在染毒柜内染毒,每周5次,每次吸入4 h,共4个月。研究了3种氟化铅气溶胶浓度(0.49±0.005,5.03±0.06,50.03±0.73 mg/m~3)的毒性作用;研究了该物质对大鼠的生殖系统作用和致突变作用,于实验后第2,3,4个月和恢复期处死动物,取股骨骨髓作网织细胞微核测定。结果表明,当浓度为50 mg/m~3时,只有实验第4个月时微核数增多,经一个月恢复。在各浓度作用下,大鼠的睾丸功能有改变,但形态学方面未见异常。
Lead fluoride is a translucent tablet made of white powder of different particle sizes. The rats in the experiment were exposed to the poisoning cabinet five times a week for 4 hours each for 4 months. The toxic effects of three lead fluoride aerosols (0.49 ± 0.005, 5.03 ± 0.06 and 50.03 ± 0.73 mg / m ~ 3) were studied. The effects of the substance on the reproductive system and the mutagenicity of the rats were studied. Animals were sacrificed at 2, 3, 4 months and recovery, and femur bone marrow was taken as reticulocyte micronucleus test. The results showed that when the concentration was 50 mg / m ~ 3, the number of micronuclei increased only at the fourth month of the experiment and recovered after one month. Under the action of each concentration, the testicular function of rats changed, but no abnormalities were found in morphology.