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目的：探索非诺贝特对缺血性脑血管疾病（ＩＣＶＤ）病人血脂成分的影响。方法：缺血性脑血管疾病伴血清脂质成分异常病人５４例（男性３２例，女性２２例；年龄５４±ｓ１２ａ）。非诺贝特０．１ｇ，ｐｏ，ｔｉｄ，４Ｗｋ为一个疗程。结果：治疗后血清ＨＤＬ一ｃｈ及ＨＤＬ２－ｃｈ、ＨＤＬ２－ｃｈ明显提高（Ｐ＜０．０１或Ｐ＜０．０５），其升高的，总有效率，依次为１００％，９６％及７７％。ＴＣ，ＴＧ及ＬＤＬ－ｃｈ显著下降（Ｐ＜０．０１或Ｐ＜０．０５），其降低的总有效率依次为９５％，１００％及７６％，不良反应轻微。结论：非诺贝特能迅速调整血脂成分及含量，可延缓或减轻动脉硬化的形成，是治疗ＩＣＶＤ病人较满意的药物。
Objective: To explore the effect of fenofibrate on the blood lipid components in patients with ischemic cerebrovascular disease (ICVD). Methods: Fifty-four patients (32 males and 22 females; age 54 ± s12a) with ischemic cerebrovascular disease and abnormal serum lipid components were included. Fenofibrate 0.1g, po, tid, 4Wk for a course of treatment. Results: After treatment, the levels of HDL-ch, HDL2-ch and HDL2-ch were significantly increased (P <0.01 or P <0.05), and the total effective rates were 100%, 96% and 77% %. TC, TG and LDL-ch were significantly decreased (P <0.01 or P <0.05), and the total effective rate was 95%, 100% and 76% respectively, with mild adverse reactions. Conclusion: Fenofibrate can rapidly adjust blood lipid composition and content, can delay or reduce the formation of atherosclerosis, ICVD patients are more satisfied with the drug.