Synthesis,Crystal Structure and Interaction with DNA of a Novel Chromium(Ⅲ) Complex Containing Salic

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The novel chromium(Ⅲ ) complex with salicylaldehyde semicarbazone was synthe- sized and characterized by IR spectra and single-crystal X-ray diffraction analysis. The crystal belongs to the orthorhombic system, space group Pbca with a = 8.9849(13), b = 12.0475(16), c = 34.522(5) , V = 3736.9(9)3, Z = 8, C16H18ClCrN6O5, Mr = 461.81, Dc = 1.642 g/cm3, F(000) = 1896, μ(MoKα) = 0.799 mm-1, the final R = 0.0370 and wR = 0.0827 for 2908 observed reflections with I > 2σ(I). The interaction between the chromium(Ⅲ ) complex with calf thymus DNA (Ct-DNA) has been investigated by absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. The results indicated that the complex was bonded to Ct-DNA through a non-classical intercalative mode. The novel chromium (Ⅲ) complex with salicylaldehyde semicarbazone was synthe- sized and characterized by IR spectra and single-crystal X-ray diffraction analysis. The crystal belongs to the orthorhombic system, space group Pbca with a = 8.9849 (13), b = (16), C = 34.522 (5) , V = 3736.9 (9) 3, Z = 8, C16H18ClCrN6O5, Mr = 461.81, Dc = 1.642 g / = 0.799 mm -1, the final R = 0.0370 and wR = 0.0827 for 2908 observed reflections with I> 2σ (I). The interaction between the chromium (Ⅲ) complex with calf thymus DNA (Ct-DNA) has been investigated by absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. The results indicated that the complex was bonded to Ct-DNA through a non-classical intercalative mode.
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