【摘 要】
：
A non-noble metal catalyzed hydrative cyclization of aldehyde-ynamides for efficient and practical synthesis of medium-sized lactams (7-to 9-membered rings) is disclosed.Compared with previous hydrative cyclization for the formation of six-membered lactam
【机 构】
：
Key Laboratory of Chemical Biology of Fujian Province,State Key Laboratory of Physical Chemistry of
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A non-noble metal catalyzed hydrative cyclization of aldehyde-ynamides for efficient and practical synthesis of medium-sized lactams (7-to 9-membered rings) is disclosed.Compared with previous hydrative cyclization for the formation of six-membered lactams (cis-form),a totally inverse diastereoselectivity (trans-form) of medium-sized lactams is observed.In addition,this protocol delivers valuable medium-sized lactams in moderate to good yields with high diastereoselectivities.Moreover,a rational mechanism to understand this inversion of diastereoselectivity is proposed based on theoretical calculations.
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