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目的探讨上皮型钙黏蛋白复合体在膀胱移行细胞癌中的表达与其生物学行为的关系及临床意义。方法应用免疫组织化学SP法检测上皮型钙黏蛋白(E-cad)、α-连接素、β-连接素(-αctn、-βctn)在60例膀胱癌组织中的表达。结果60例膀胱癌标本中,E-cad,-αctn及-βctn膜异常表达率为68.3%(41/60)、66.7%(40/60)和61.6%(37/60),三者膜异常表达率在低分化肿瘤中显著高于高分化肿瘤,浸润型显著高于表浅型;在复发性肿瘤中,E-cad和-βctn膜异常表达率显著高于初发性肿瘤,而-αctn在两者中无明显差异。结论在膀胱癌中普遍存在上皮型钙黏蛋白复合体的异常表达,其表达下调与膀胱癌的恶性程度有关,尤其是E-cad和-βctn表达下调是判断膀胱癌复发的有用指标。
Objective To investigate the relationship between the expression of epithelial cadherin complex in bladder transitional cell carcinoma and its biological behavior and its clinical significance. Methods The expression of E-cadherin, α-catenin, β-catenin (-αctn, -βctn) in 60 cases of bladder cancer was detected by immunohistochemistry SP method. Results The abnormal expression rates of E-cad, -ctin and -βctn in 60 specimens of bladder cancer were 68.3% (41/60), 66.7% (40/60) and 61.6% (37/60), respectively The expression rate in poorly differentiated tumors was significantly higher than that in well differentiated tumors, and infiltrating type was significantly higher than that in superficial type. In recurrent tumors, the abnormal expression rates of E-cad and -βctn were significantly higher than those in primary tumors, There is no significant difference between the two. Conclusion The abnormal expression of E-cadherin complex exists in bladder cancer. The down-regulation of E-cadherin complex is associated with the malignant degree of bladder cancer. The down-regulation of E-cad and -βctn expression is a useful indicator to judge the recurrence of bladder cancer.