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一、引言人癌瘤的分子生物学知识在过去五年有很大发展,最突出的发现是染色体改变的定位与各种细胞癌基因位点的关系.并在几种不同类型的人肿瘤中已获得选择性单一复制基因扩大的证据.本文简述人乳癌染色体改变的现代知识及对乳癌瘤基因的表达和扩大提供一般观察.二、人乳癌中细胞遗传学的改变(一)染色体的改变:历史的观点.实际上人实体瘤的细胞遗传学检查已明显落后
I. INTRODUCTION The molecular biology of human carcinomas has greatly developed over the past five years, with the most prominent finding being the relationship between the location of chromosomal alterations and the various cellular oncogene loci. In several different types of human tumors Evidence of the expansion of selective single-copy genes has been obtained.This article briefly reviews the modern knowledge of chromosomal alterations in human breast cancer and provides general observations on the expression and expansion of breast cancer genes.2.Changes in Cytogenetics in Human Breast Cancer (a) Changes in Chromosomes : Historical Perspectives. In fact, the cytogenetic examination of human solid tumors has lagged far behind