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目的分析不同程度及转归的孤立性侧脑室扩张(IV)与生后0~6岁智能、体格发育的相关性。方法选择2007.1.1~2013.1.1于济宁医学院附属医院行超声发现IV的患儿186例为研究组。选择同期于本院受检的0~6岁正常婴幼儿200例为对照组。两组进行丹佛发育筛查(DDST)和体格发育测量,将不同程度及转归的研究组分别与对照组比较。结果轻度扩张的进展型、中度扩张的进展型和稳定型、重度扩张的3种类型与对照组差异有统计学意义。DDST异常及可疑者与年龄呈正相关。两组体格发育差异无统计学意义。结论轻度扩张的进展型、中度扩张的进展型和稳定型、重度扩张的3种类型可导致智能发育障碍,随着年龄增加而增多,对于早期未发现异常的高危儿应重视远期随访。IV对体格发育无影响。
Objective To analyze the correlation between the degree of isolation and outcome of solitary lateral ventricle dilation (IV) and intelligence and physical development of 0-6 years old after birth. Methods Totally 186 children with IV found by ultrasound in Affiliated Hospital of Jining Medical College from January 2007 to April 2013 were selected as the research group. Select the same period in our hospital under the age of 0 to 6-year-old 200 cases of normal infants as a control group. The two groups were measured by Denver Developmental Screening (DDST) and physical development, and the study groups with different degrees and outcomes were respectively compared with the control group. Results of mild expansion of the progressive, moderate expansion of the progressive and stable, severe expansion of the three types of differences with the control group was statistically significant. Abnormal DDST and suspicious persons were positively correlated with age. There was no significant difference in physical development between the two groups. Conclusions The three types of progressive and stable mode of mild dilatation, moderate dilatation and moderate dilatation may lead to mental retardation, which increases with age. Long-term follow-up should be emphasized in high-risk infants with no early abnormalities . IV has no effect on physical development.