新生儿溶血病(HDN)是由母亲体内含有针对胎儿红细胞上父源性抗原的抗体所致,严重时可使胎儿宫内死亡。尽管用抗-D预防可降低发病率,每年仍有大量病例出现。产前检查的目的是预测胎儿是否受到影响,如果受到影响就要矫正贫血和选择最佳分娩时间。间接方法包括母亲血标本抗体定量和羊膜穿刺测定羊水中胆红素含量,直接方法是取胎儿血样测定其抗原、血红蛋白和红细胞压积。采集胎儿血标本和羊水均为损伤 Neonatal hemolytic disease (HDN) is caused by the mother’s body contains antibodies against the parent antigen on the fetal red blood cells, severe intrauterine fetal death. Although anti-D prevention can reduce the incidence, there are still a large number of cases every year. The purpose of prenatal examination is to predict whether the fetus is affected, to correct anemia and to choose the optimal delivery time if affected. Indirect methods include the quantification of the antibody of the mother’s blood and the amniocentesis for the determination of bilirubin in amniotic fluid. The direct method is to measure the antigen, hemoglobin and hematocrit of the fetus. Collect fetal blood samples and amniotic fluid are damaged