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已知可乐宁对轻、中、重度高血压均有效,通常采用一日三次给药法。最近研究表明药物半衰期在正常血压者为12·7小时,在高血压者为7·9～11·4小时。一日二次给药可维持降压作用所需的血浆浓度(0.15～2.2毫微克/毫升)。本文报告18例原发性高血压患者采用一日二次给药法的降压效果。患者年龄:30～61岁(平均43±14岁)按WHO分期属Ⅰ—Ⅱ期。诊断标准是在休息15分钟后卧位测血压三次,收缩压≥160mmHg与/
It is known that clonidine is effective for light, moderate and severe hypertension, usually three times a day. Recent studies show that the half-life of drugs in the normal blood pressure was 12.7 hours, in those with hypertension was 7.9-1.4 hours. The twice-daily dosing will maintain the plasma concentration required for the antihypertensive effect (0.15-2.2 ng / mL). This article reports 18 patients with essential hypertension in patients with a second day administration of antihypertensive effect. Patients age: 30 to 61 years (mean 43 ± 14 years) according to WHO staging is Ⅰ-Ⅱ period. The diagnostic criteria is to measure blood pressure three times in the supine position after resting for 15 minutes, systolic blood pressure ≥ 160 mmHg and /