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目的 :观察吡哌酸滴耳剂治疗化脓性中耳炎的疗效。方法 :应用 0 .2 %吡哌酸滴耳剂治疗 40例慢性中耳炎患者 ,疗程 7d,分别于用药后第 3天和第 7天进行临床症状、体征及细菌学检查 ;同时用 0 .2 5%的氯霉素滴耳剂作对照。结果 :吡哌酸滴耳剂 3d后有效率和细菌清除率为 65%和 60 % ,7d后分别为 92 .5%和90 % ,氯霉素滴耳剂临床有效率和细菌清除率 3d为 42 .5%和 40 % ,7d后分别为 62 .5%和 60 % ,差异有显著性 (P<0 .0 1 )。结论 :吡哌酸滴耳剂治疗慢性化脓性中耳炎高效、安全。
Objective: To observe the efficacy of pipemidic acid eardrops in the treatment of suppurative otitis media. Methods: Forty patients with chronic otitis media were treated with 0 .2% pipemidic acid eardrops for 7 days. Clinical symptoms, signs and bacteriological examination were performed on the 3rd and 7th day after treatment. At the same time, % Chloramphenicol ear drops as a control. Results: The effective rate and bacterial clearance rate of piperine ear drops were 65% and 60% after 3 days and 92.5% and 90% respectively after 7 days. The clinical efficacy and bacterial clearance rate of chloramphenicol ear drops were 3d 42.5% and 40%, respectively. After 7 days, they were 62.5% and 60% respectively, with significant difference (P <0.01). Conclusion: Pipemidic acid ear drops in the treatment of chronic suppurative otitis media is effective and safe.