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报告1例皮肤颗粒细胞瘤并发局部多毛.患者女,62岁.右前臂屈侧结节10年,偶伴疼痛或瘙痒.皮肤科检查:右前臂屈侧一1.5 cm×1.0 cm淡黄色结节,上覆少许褐色鳞屑,周边可见毛发,质硬.皮损组织病理检查:肿瘤团块位于真皮内,肿瘤细胞呈条索状分布,胞体大,核小呈圆形,胞质红染,充满嗜酸性颗粒物质.免疫组化:S-100蛋白、神经元特异性烯醇化酶(NSE)、转录因子SOX-10及CD68均阳性.诊断:皮肤颗粒细胞瘤.“,”A case of cutaneous granular cell tumor with localized hypertrichosis is reported.A 62-year-old woman had had a nodule,with causal pain and itching,on the right forearm flexor for 10 years.Dermatological examination showed a firm yellowish nodule sized 1.5 cm × 1.0 cm,covered with brown scales,and surrounded by hair,on the right forearm flexor.Histopathological examination showed the large tumor cells,with small round nuclei,arranged in cord-like form in the dermis.The cytoplasm appeared red and contained abundant eosinophilic granular materials,Immunohistochemistry of tumor cells showed positive for S-100 protein,NSE,SOX-10 and CD68.The diagnosis was cutaneous granular cell tumor.