三苯氧胺是雌激素受体阳性的乳腺癌患者内分泌治疗的首选药物。其抗雌激素作用用于乳腺癌治疗,但类雌激素样的作用可能导致子宫内膜病变,长期使用可增加子宫内膜癌的发病率。本文旨在探讨三苯氧胺引起子宫内膜病变的作用机制以及左炔诺孕酮宫内缓释系统(曼月乐)对三苯氧胺引起的相关子宫内膜病变的治疗及预防作用。 Tamoxifen is the drug of choice for endocrine therapy in patients with estrogen receptor-positive breast cancer. Its anti-estrogen action for breast cancer treatment, but the role of estrogen-like endometrial lesions may lead to long-term use can increase the incidence of endometrial cancer. This article aims to investigate the role of tamoxifen in the pathogenesis of endometrial lesions and levonorgestrel intrauterine release system (Mirena) on the tamoxifen-induced endometrial lesions in the treatment and prevention.