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目的探讨康妇消炎栓联合阿奇霉素与单纯使用阿奇霉素治疗支原体感染性盆腔炎的疗效。方法选择2014年1月—2015年12月杭州市妇产科医院妇科门诊收治的112例支原体感染盆腔炎患者为研究对象。按照入院先后将患者分为对照组和治疗组,每组56例。对照组患者给予用阿奇霉素静脉滴注,0.5 g/次,1次/d,2 d后改用阿奇霉素口服制剂0.25 g/d,1次/d。治疗组在上述基础上同时给予康妇消炎栓塞肛,每晚1支。2组患者7 d为1个疗程,一共6个疗程。观察对比2组患者临床效果、用药安全性和外周血T细胞亚群的变化。文中所得数据采用SPSS 17.0统计软件进行处理。结果治疗组患者临床有效率显著优于对照组(χ~2=3.95,P<0.05)。治疗组不良反应发生率为8.93%,低于对照组的12.50%,但差异无统计学意义(P>0.05)。2组患者用药后,血、尿、粪常规、肝功能未见明显异常,安全性较高。治疗后,治疗组外周血T细胞亚群CD4~+百分比为(45.51±5.15)%,显著高于对照组的(43.89±4.06)%,CD8~+百分比为(35.92±3.05)%,显著低于对照组的(37.06±3.25)%、CD4~+/CD8~+比例显著高于对照组,差异有统计学意义。结论康妇消炎栓联合阿奇霉素治疗支原体感染盆腔炎疗效良好,安全性高,不良反应少,外周血T淋巴细胞亚群比例显著改善。
Objective To investigate the curative effect of Kangfu anti-inflammatory suppository combined with azithromycin and azithromycin alone in the treatment of mycoplasmal infection pelvic inflammatory disease. Methods From January 2014 to December 2015, 112 cases of mycoplasma-infected patients with pelvic inflammatory disease underwent gynecology clinic in Hangzhou Obstetrics and Gynecology Hospital. In accordance with admission, the patients were divided into control group and treatment group, 56 cases in each group. Patients in the control group were given azithromycin intravenously, 0.5 g / time, once / d, 2 d after the switch to azithromycin oral 0.25 g / d, 1 / d. The treatment group on the basis of the above concomitant anti-inflammatory embolism, 1 night. 2 days 7 days for a course of treatment, a total of 6 courses. The clinical effects, medication safety and the changes of T lymphocyte subsets in the two groups were observed and compared. The data obtained in this paper using SPSS 17.0 statistical software for processing. Results The clinical efficiency of the treatment group was significantly better than that of the control group (χ ~ 2 = 3.95, P <0.05). The incidence of adverse reactions in the treatment group was 8.93%, which was lower than that in the control group (12.50%), but the difference was not statistically significant (P> 0.05). 2 groups of patients after treatment, blood, urine, fecal routine, no significant abnormal liver function, high safety. After treatment, the percentage of CD4 ~ + in peripheral blood T lymphocyte subsets was (45.51 ± 5.15)% in the treatment group, significantly higher than that in the control group (43.89 ± 4.06)%, and the percentage of CD8 + was (35.92 ± 3.05)% In the control group (37.06 ± 3.25)%, the ratio of CD4 ~ + / CD8 ~ + was significantly higher than the control group, the difference was statistically significant. Conclusion Kangfu anti-inflammatory suppository combined with azithromycin in the treatment of mycoplasma infection of pelvic inflammatory disease with good effect, high safety, fewer adverse reactions, peripheral blood T lymphocyte subsets significantly improved.