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目的了解青海省西宁市儿童人肠道病毒71型(human enterovirus 71,HEV 71)抗体水平及自然感染状况,为预防控制儿童手足口病传播与流行提供依据。方法于2009年5-8月采集西宁市2个区(县)181名1~6岁儿童血清标本,采用中和试验检测血清HEV71中和抗体,并对检测结果进行统计学分析。结果儿童HEV 71中和抗体阳性68人,阳性率为37.6%,HEV71中和抗体几何平均滴度水平为1∶16.12;随着年龄的增大,抗体阳性率及几何平均滴度升高,各年龄组抗体阳性率、几何平均滴度差异均有统计学意义(χ2=41.89,P<0.05;F=4.94,P<0.05);西宁市1~6岁儿童HEV71中和抗体构成以抗体阴性为主。结论西宁市1~6岁儿童尤其是≤3岁儿童是目前手足口病防控的重点人群。
Objective To understand the antibody level and natural infection of human enterovirus 71 (XE) in children in Xining, Qinghai Province, and to provide basis for prevention and control of the spread and epidemic of hand-foot-mouth disease in children. Methods A total of 181 serum samples from 1 to 6 years old from 2 districts and counties in Xining City were collected from May to August in 2009. Neutralization test was used to detect the neutralizing antibody of HEV71 in serum. Statistical analysis of the results was made. Results The positive rate of HEV 71 neutralizing antibody in 68 children was 37.6%. The geometric mean titer of HEV71 neutralizing antibody was 1:16.12. With the increase of age, the antibody positive rate and geometric mean titer increased The antibody positive rate and geometric mean titer in age group were significantly different (χ2 = 41.89, P <0.05; F = 4.94, P <0.05). The neutralizing antibody of HEV71 in children aged 1 ~ 6 years the Lord. Conclusion Xilian children aged 1 ~ 6 years, especially children ≤ 3 years old, are the key population of prevention and control of HFMD.