血管阻力增高是大多数慢性高血压患者血压升高的主要因素。降低心排出量或血管阻力能使血压正常,但低心排出量可使循环状态更不正常,出现低灌注状态。所以,抗高血压治疗的理想血液动力学效应是直接作用于血管而扩张小动脉平滑肌,不影响心脏或降低静脉回流。钙拮抗剂能特异性地抑制细胞外钙穿过细胞膜和钙离子从肌浆网的结合部位进入细胞浆,从而抑制平滑肌收缩,使心脏收缩降低、冠状动脉和体循环血管扩张。本文旨在评价长期 Increased vascular resistance is the major cause of blood pressure in most patients with chronic hypertension. Reduce cardiac output or vascular resistance can make blood pressure normal, but low cardiac output can make the circulatory state is more abnormal, low perfusion state. Therefore, the ideal hemodynamic response to antihypertensive treatment is to act directly on the blood vessels to dilate the arteriolar smooth muscle, without affecting the heart or reducing venous return. Calcium antagonists can specifically inhibit the extracellular calcium through the cell membrane and calcium ions from the sarcoplasmic reticulum binding sites into the cytoplasm, thereby inhibiting smooth muscle contraction, reducing cardiac contractility, coronary artery and systemic vascular dilatation. This article aims to evaluate the long term