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黄早4是玉米制种利用最广的骨干自交系。80年代以来,黄早4上普遍发生一种危害较大的新病害,群众称为黄斑病。此病主要危害叶片,亦危害叶鞘和苞叶。抽雄后病害迅速扩展蔓延,植株布满病斑,叶片提早干枯,一般减产20％～30％,严重地块减产50％以上,甚至绝收。除黄早4外,掖107、丹340、E28、承223、M017、215、L105、N27、黄野4等自交系及一些杂交种也不同程度感病。黄斑病已成为玉米制种的一大障碍。
Huangzao 4 is the most widely used backbone of maize inbred lines. Since the 1980s, Huang Zhaoli 4 has a new and harmful new disease, and the masses are called maculopathy. The disease is mainly endangering leaves, also endanger leaf sheaths and bracts. After tasseling rapid expansion of disease spread, plants covered with spots, leaves early dry, the general reduction of 20% to 30%, a serious block cut more than 50%, or even absolutely. In addition to Huang Zao 4, Ye 107, Dan 340, E28, Cheng 223, M017, 215, L105, N27, Huang Ye 4 and other inbred lines and some hybrids are also susceptible to varying degrees. Macula has become a major obstacle to seed production in maize.