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目的:汉化16个条目版的癫痫儿童健康相关生活质量特异性量表（QOLCE-16），并在中国癫痫儿童中进行信、效度分析。方法:采用国际标准的慢性病治疗功能评价翻译方法，由3名具备双语的翻译人员对源量表进行前译，由另外3名具备双语的翻译人员进行回译，并通过认知性访谈以及专家咨询对量表进行调试。采用方便抽样法，选取2020年6—12月在上海市儿童医院神经专科就诊的256例癫痫患儿，所有量表均由长期照顾者代为填答，最终有效回收256份，分析经文化调试后的QOLCD-16在癫痫患儿健康相关生活质量测评中的信度和效度。在样本中选取40例研究对象，间隔2~3周再次填写中文版QOLCE-16，最终有效回收32例样本评价量表的重测信度。结果:中文版QOLCE-16共有16个条目，包括认知、情感、社交、身体机能4个维度。各条目均具有良好的鉴别度，且与量表总分之间呈显著相关（n P<0.05）。专家量表水平内容效度指数（n S-n CVI）为1.00，条目水平的内容效度指数（n I-n CVI）为0.89~1.00。探索性因子分析n KMO值为0.909，4个维度特征值分别为3.482、3.223、3.136、2.955，累积方差贡献率为79.976%。量表Cronbach\'s α系数为0.938，各维度Cronbach\'s α系数为0.866~0.939；分半信度为0.814，各维度分半信度为0.840~0.942；量表重测信度为0.724，各维度重测信度为0.615~0.716。n 结论:中文版QOLCE-16具有良好的信度和效度，可作为4~18岁癫痫儿童健康相关生活质量评估的简易工具。“,”Objective:To translate the 16-item version of Quality of Life in Children with Epilepsy (QOLCE-16) into Chinese, and conduct reliability and validity analysis in Chinese children with epilepsy.Methods:The International Functional Assessment of Chronic Illness Therapy (FACIT) translation method was adopted. Three bilingual translators pre-translated the source scale, and another three bilingual translators performed back translation. The QOLCE-16 was adjusted through the cognitive interview and expert consultation. This study was a cross-sectional study. Convenience sampling was used to select 256 children with epilepsy who were admitted to the Department of Neurology of Children\'s Hospital of Shanghai from June to December 2020. All questionnaires were filled out by long-term caregivers, and 256 copies were finally recovered effectively to analyze the reliability and validity of the QOLCE-16 after cultural adjustment in the evaluation of the health-related quality of life of children with epilepsy. A total of 40 subjects were selected from the sample, and the Chinese version of QOLCE-16 was filled out again at an interval of 2 to 3 weeks. Finally, 32 samples were effectively recovered to evaluate the test-retest reliability of the scale.Results:The Chinese version of QOLCE-16 had 16 items in total, including 4 dimensions of cognition, emotion, social interaction, and physical function. Each item had a good degree of discrimination, and there was a statistical correlation with the total score of the scale (n P<0.05) . The scale-level content validity index (n S-n CVI) was 1.00, and the item-level content validity index (n I-n CVI) was from 0.89 to 1.00. The n KMO value of exploratory factor analysis was 0.909, the eigenvalues of each dimension were 3.482, 3.223, 3.136, 2.955 respectively, and the cumulative variance contribution rate was 79.976%. The Cronbach\'s α coefficient of the scale was 0.938, and the Cronbach\'s α coefficient of each dimension was from 0.866 to 0.939. The split-half reliability was 0.814, and the split-half reliability of each dimension ranged from 0.840 to 0.942. The test-retest reliability of the scale was 0.724, and the test-retest reliability of each dimension was from 0.615 to 0.716.n Conclusions:The Chinese version of QOLCE-16 has good reliability and validity, and can be used as a simple tool for evaluating the health-related quality of life of children with epilepsy between 4 and 18 years of age.