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目的分析研究郴州市第三人民医院新生儿科确诊的62例早产儿败血症患者的临床特点及治疗方法。方法采用回顾性分析,对62例确诊为早产儿败血症的危险因素、主要感染途径、实验室检查指标进行统计分析。并随机选择同期该院新生儿科收治的62例确诊未患败血症早产儿的临床资料进行比对。结果胎膜早破及胎心晚期减速是早产儿患败血症的主要危险因素。早产儿败血症感染途径主要为呼吸道感染,白细胞计数(WBC)>20×109/L或<5×109/L,血小板计数(PLT)<100×109/L,C反应蛋白(CRP)>8 mg/L,可作为早期诊断败血症的辅助指标并具有一定特异性。丙种球蛋白联合敏感抗生素治疗,其治愈率显著高于单纯使用抗生素组。结论提高对危险因素的认识,早期诊断早产儿败血症是合理治疗的前提;使用抗生素加丙种球蛋白,是治疗早产儿败血症的有效方法。
Objective To analyze the clinical features and treatment of 62 cases of premature infant septicemia diagnosed in Neonatology Department of Third People’s Hospital of Chenzhou City. Methods A retrospective analysis of 62 cases of preterm children diagnosed as risk factors for sepsis, the main route of infection, laboratory tests for statistical analysis. And randomly selected the same period the hospital neonatology admitted 62 cases of premature children without confirmed sepsis clinical data for comparison. Results Premature rupture of membranes and late fetal heart rate deceleration are the main risk factors for sepsis in preterm infants. The main pathways of sepsis infection in preterm infants were respiratory infection, white blood cell count (WBC)> 20 × 109 / L or <5 × 109 / L, platelet count <100 × 109 / L, CRP> 8 mg / L, can be used as an auxiliary indicator of early diagnosis of sepsis and has a certain specificity. Gamma globulin combined with sensitive antibiotics, the cure rate was significantly higher than the simple use of antibiotics group. Conclusions To improve the understanding of risk factors, early diagnosis of premature infant septicemia is a prerequisite for rational treatment. The use of antibiotics plus gamma globulin is an effective treatment for sepsis in preterm infants.