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曾有报导指出metergoline是抗血清素制剂,可使正常人、产褥期及高催乳素血症性闭经病人的PRL降低,导致月经来潮及恢复生育力.本文研究目的在于对用固定方案metergoline治疗大批闭经或无排卵以及溢乳症患者的疗效作出估价.在观察期间均通知病人严格遵守用非激素的避孕措施.作者对84例高催乳素血症患者(血PRL范围为25～253ng/ml),用metergoliae治疗,开始剂量为2mg,一日两次,以后每日增加至12mg,共90天.主诉闭经70例(其中有溢乳者44例),无排卵者14例(6例有溢乳).这些病人经询问病史,体格检查,测定血清FSH、LH、PRL、甲状腺素、三碘甲腺原氨酸及尿17-羟、17-酮/24小时,
It has been reported that metergoline is an anti-serotonin preparations, can make normal, puerperium and hyperprolactinemia in patients with PRL decreased, leading to menstrual cramps and restore fertility.The purpose of this study is to use a fixed schedule metergoline treatment of a large number of amenorrhea Or anovulation and the efficacy of galactorrhea in patients were observed during the observation of patients were strictly observed with non-hormonal contraceptive measures 84 patients with hyperprolactinemia (blood PRL range of 25 ~ 253ng / ml) with metergoliae treatment, the initial dose of 2mg, twice a day, after a daily increase to 12mg, a total of 90 days.Among the main complaint of amenorrhea in 70 cases (including 44 cases of galactorrhea), anovulatory in 14 cases (6 cases of galactorrhea) The patient was asked to ask medical history, physical examination, serum FSH, LH, PRL, thyroxine, triiodothyronine and urinary 17-hydroxy, 17-keto / 24 hours,