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血管内皮生长因子受体(vascular endothelial growth factor receptors,VEGFRs)包括Flt-1(VEGFR1),KDR/Flk-1(VEGFR2)和Flt-4(VEGFR3),三者在血管新生中均起着重要的作用。然而,最近的研究还表明,Flt-1不仅与血管新生密切相关,在血液系统中亦有重要作用:在多种血液细胞表达,能够调控造血重建,为血液系统疾病提供很好的治疗靶点。因此,阐明Flt-1在血液系统中的表达及作用,对于治疗血液系统疾病,是非常有益的。
Vascular endothelial growth factor receptors (VEGFRs) include Flt-1 (VEGFR1), KDR / Flk-1 (VEGFR2) and Flt-4 (VEGFR3), all of which play an important role in angiogenesis effect. However, recent studies have also shown that Flt-1 is not only closely related to angiogenesis but also plays an important role in the blood system: it is expressed in many blood cells and can regulate hematopoietic reconstitution and provide a good therapeutic target for hematological diseases . Therefore, to clarify the expression and role of Flt-1 in the blood system is very beneficial for the treatment of diseases of the blood system.