近年研究表明,子痫前期的一个重要的临床特征是循环系统中血管生成因子和血管生成抑制因子的失衡。血小板反应蛋白(thrombospondin,TSP)来自多种细胞,如血小板、内皮细胞、基质纤维细胞、血管平滑肌细胞、间质细胞和免疫细胞,参与多种细胞功能,TSP有抑制血管形成的作用。TSP可能通过激活内皮细胞的增殖、迁移、黏附及浸润使内皮功能受损,进一步导致子宫螺旋动脉管腔狭窄、闭锁,引起胎盘血流灌注减少,引发子痫前期。 Recent studies have shown that one of the most important clinical features of preeclampsia is the imbalance of angiogenic and angiogenic inhibitors in the circulatory system. Thrombospondin (TSP) is derived from a variety of cells, such as platelets, endothelial cells, stromal fibroblasts, vascular smooth muscle cells, interstitial cells and immune cells involved in a variety of cellular functions, TSP has the role of inhibiting angiogenesis. TSP may activate the endothelial cell proliferation, migration, adhesion and infiltration of endothelial dysfunction, uterine spiral lumen further lead to stenosis, atresia, causing decreased placental perfusion, triggering preeclampsia.