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目的观察胸腔热化疗治疗恶性胸腔积液的疗效,探讨有效治疗恶性胸腔积液的方法。方法 68例恶性胸腔积液住院病人,男性43例,女性25例;平均年龄65岁。随机分成2组:观察组38例,采用胸腔内置管热化疗;对照组30例,采用顺铂100mg/m2胸腔内注入。对2组病人的中位生存率、生活质量等进行评估。结果经过4周治疗后,观察组中位生存率及Karnofsky评分明显高于对照组(P均<0.05);观察组总有效率为81.6%,高于对照组(43.3%)(P<0.05)。结论胸腔内热化疗治疗恶性胸腔积液有效率高,毒副作用小,病人易于耐受。
Objective To observe the curative effect of thoracic thermochemotherapy on malignant pleural effusion and to explore the effective treatment of malignant pleural effusion. Methods 68 cases of malignant pleural effusion hospitalized patients, 43 males and 25 females; the average age of 65 years. Randomly divided into two groups: the observation group of 38 cases, the use of thoracic tube thermotherapy; control group of 30 patients with cisplatin 100mg / m2 intrathoracic injection. The median survival and quality of life of the two groups were evaluated. Results After 4 weeks of treatment, the median survival rate and Karnofsky score in the observation group were significantly higher than those in the control group (all P <0.05). The total effective rate in the observation group was 81.6%, higher than that in the control group (43.3%) (P <0.05) . Conclusions Intrathoracic thermochemotherapy is effective in treating malignant pleural effusion with small toxic and side effects and is easily tolerated in patients.