糖部分修饰的核苷类似物,作为有效的抗肿瘤及抗病毒药物,受到广泛的注意。但木糖系列则研究得较少。据报道木糖苷也显示抗肿瘤活性,木糖腺苷虽呈一定的抗肿瘤活性,但毒性较大。为了进一步研究木糖苷类似物的药理作用,我们合成了一系列8-取代的β-D-呋喃型木糖基腺嘌呤。 Sugar partially modified nucleoside analogs, as an effective anti-tumor and anti-viral drugs, receive extensive attention. However, the xylose series is less studied. It has also been reported that xyloside also shows antitumor activity, although xylitoside shows some antitumor activity but is more toxic. In order to further study the pharmacological effects of xyloglucoside analogs, we synthesized a series of 8-substituted β-D-furanosyl adenosine.