论文部分内容阅读
英国药典法定的片剂崩解度只限于片剂在水中崩解能通过10目筛的粒子。这可能是易被误解的准则,特别是对溶解度小的药片当采用较小的粒子时可加速其溶解。作者以几种磺胺嘧啶-玉米淀粉片剂作试验,用湿筛法和粒子计数法测定片剂崩解后粒度大小的全部分布情况。磺胺嘧啶片用聚乙烯吡咯烷酮(PVP)作粘合剂,淀粉分为内加(做入颗粒内)与外加二种情况,不加滑润剂。然后以适当的压力压片并测定片剂的硬度。实验分三步进行:(1)测定崩解时间;(2)采用湿筛法将崩解后的混悬液通过10种不同孔径(12目～200目)的筛子分别筛
The United Kingdom Pharmacopoeia statutory tablet disintegration is limited to tablets that disintegrate in water to pass through a 10 mesh sieve. This may be a misleading guideline, especially for less soluble tablets that speed up dissolution when using smaller particles. The authors tested several tablets of sulfadiazine-corn starch and determined the distribution of the size of the tablet after disintegration using a wet sieving method and a particle counting method. Sulfadiazine tablets with polyvinylpyrrolidone (PVP) as a binder, the starch is divided into the internal plus (into the particles) and plus two cases, without lubricant. The tablets are then tableted at the appropriate pressure and the hardness of the tablets is determined. The experiment is divided into three steps: (1) measuring the disintegration time; (2) using the wet sieving method, the disintegrated suspension is sieved through 10 sieves with different diameters (12 meshes to 200 meshes)