第一代喹诺酮类（Quinolones）药物萘啶酸（Nalidixicacid）是由美国Sterling—Winthrop研究所Lesher等在1962年发现，随后许多学者致力于研究开发这类药物，1972年合成了第二代一吡哌酸（PIPemidicacid），1977年合成了第三代一氟呗酸（Norfloxacin），第三代隆诺SM类药物比第 The first generation of Quinolones drug, Nalidixic acid, was discovered in 1962 by Lesher et al. At the Sterling-Winthrop Institute in the United States. Subsequently, many scholars devoted themselves to the research and development of such drugs. In 1972, Piperazine acid (PIPemidicacid), in 1977 synthesized the third generation of monofluoro acid (Norfloxacin), the third generation of Rono SM class than the first