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探讨细胞因子在 Graves′病发病中的作用。方法 利用高敏感固相增敏免疫分析方法 ( EASIA)测定了 36例 Graves′病伴甲亢患者 ,1 9例未治亚急性甲状腺炎和 2 8例正常人血清 IL- 6、IL- 8水平。结果 GD患者血清 IL- 6、IL- 8浓度高于正常人水平 ( P1<0 .0 5,P2 <0 .0 5)。 IL- 6升高的 GD患者占 2 2 .2 2 % ( 8/36)。 IL - 6水平与 IL- 8不相关 ( P >0 .0 5)。 IL - 6水平与 TGA、MCA和 TRAb不相关 ,与 T3 也不相关。此外 1 9例未治亚急性甲状腺炎 ( SAT)患者血清 IL - 6水平也高于正常人 ( P <0 .0 5)。结论 在 GD患者发病中存在 IL - 6、IL - 8系统的参与
To investigate the role of cytokines in the pathogenesis of Graves’ disease. Methods Serum levels of IL-6 and IL-8 were measured in 36 cases of Graves’ disease with hyperthyroidism, 19 cases of subacute thyroiditis and 28 cases of normal controls by high sensitive solid phase sensitometric immunoassay (EASIA). Results The serum levels of IL-6 and IL-8 in GD patients were higher than those in normal controls (P <0.05, P <0.05). GD patients with elevated IL-6 accounted for 22.2% (8/36). The level of IL - 6 was not correlated with IL - 8 (P> 0.05). The level of IL - 6 was not related to TGA, MCA and TRAb, nor to T3. In addition, the levels of serum IL - 6 in 19 patients with untreated subacute thyroiditis were also higher than those in normal controls (P <0.05). Conclusion There is IL - 6 and IL - 8 system involvement in the pathogenesis of GD