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目的 评价地尔硫 艹卓 对不稳定型心绞痛的临床疗效。方法 6 5例不稳定型心绞痛患者随机分为 2组。治疗组地尔硫艹卓5 0mg/d ;对照组硝酸甘油 10mg/d。 2组均加入 5 %葡萄糖溶液 2 5 0mL中静滴连用 7d。观察治疗前后痛疼缓解、HR、BP、心肌耗氧指数 (心率×收缩压 )、心电图 (ECG)的变化情况。结果 1周内地尔硫 艹卓 组疼痛缓解率、发展为AMI的病例数较硝酸甘油组有显著差异 (P <0 .0 5 ) ;地尔硫艹卓 组治疗后心肌耗氧指数较治疗前显著下降 (P<0 .0 1)。 2组治疗后HR、BP均较治疗前有非常显著差异 (P <0 .0 1)。窦性心动过缓、房室传导阻滞为治疗的不良反应。结论 与硝酸甘油相比 ,静滴地尔硫艹卓 能更有效地控制不稳定型心绞痛 ,降低心肌耗氧指数 ,减少AMI的发生。
Objective To evaluate the clinical efficacy of diltiazem on unstable angina pectoris. Methods Sixty-five patients with unstable angina were randomly divided into two groups. Treatment group Diltiazem 50mg / d; control group of nitroglycerin 10mg / d. 2 groups were added 5% glucose solution 250mL in 7d. Before and after treatment to relieve pain relief, HR, BP, myocardial oxygen consumption index (heart rate × systolic blood pressure), electrocardiogram (ECG) changes. Results The pain relief rate in Duloxetine group within 1 week was significantly higher than that in the nitroglycerin group (P <0.05). The myocardial oxygen consumption index after Diltiazem group was higher than that before treatment Significantly decreased (P <0.01). The HR and BP of the two groups after treatment were significantly different from those before treatment (P <0.01). Sinus bradycardia, atrioventricular block for the treatment of adverse reactions. Conclusion Compared with nitroglycerin, intravenous diltiazem can more effectively control unstable angina, reduce myocardial oxygen consumption index and reduce the occurrence of AMI.