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目的研究偏钒酸钠对大鼠的协调能力和记忆力的影响。方法采用重复测量方差分析偏钒酸钠对大鼠协调能力和记忆力的影响。结果①染毒后,高、低剂量组大鼠出现腹泻或鼻炎症状,每组各有2只死亡,且实验后期体重较对照组为轻。②转棒实验,3组大鼠在棒上停留的时间表现为染毒后明显下降,染毒停止后持续上升的趋势,在30 d时点上转棒时间由低到高依次为高剂量组、对照组、低剂量照组,差异有统计学意义(P<0.05)。③水迷宫实验,3组大鼠到达终点的时间存在波动且差异无统计学意义(P>0.05)。错误次数的分析发现高、低剂量组大鼠均存在错误次数基线水平低,染毒后增加,停止染毒后减少的时间趋势,对照组大鼠的错误次数在各时点轻微波动;30 d时点上错误次数从从高到低依次为高剂量组、低剂量组、对照组,差异有统计学意义(P<0.05)。结论偏钒酸钠对大鼠的协调能力有损害作用,对大鼠的记忆力可能有损害作用。
Objective To study the effect of sodium metavanadate on the coordination and memory of rats. Methods repeated measures of variance analysis of sodium metavanadate on the coordination and memory of rats. Results ① After treatment, the rats in high and low dose groups developed diarrhea or rhinitis symptoms, each of which had 2 deaths and the weight of the latter was lighter than the control group. ② The rotarod test, the time spent on the sticks of the three groups showed a significant decrease after exposure to the poisoning, and continued to increase after the cessation of exposure. At the 30th day, the time from low to high was the high-dose group , Control group, low dose group, the difference was statistically significant (P <0.05). ③ The water maze test, the time of arrival of the three groups of rats fluctuated with no significant difference (P> 0.05). The analysis of the number of errors found that the number of errors in the high and low dose groups were all low, the baseline level was low, increased after treatment, to stop the trend of reducing the time after exposure, the number of errors in the control group rats slightly fluctuated at all times; 30 d At the time point, the number of errors from high to low order high dose group, low dose group, control group, the difference was statistically significant (P <0.05). Conclusion Sodium metavanadate has a detrimental effect on the coordination ability of rats and may impair the memory of rats.