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[目的]调查分析广东省0～18岁人群恶性肿瘤发病的危险因素,为该人群恶性肿瘤的防治提供方向和思路。[方法]收集2002年12月～2005年5月广东省0～18岁恶性肿瘤病例,以病例-对照方法,用SPSS15.0统计软件进行单因素分析,选择其中有意义的因素进行多因素非条件Logistic回归分析。[结果]多因素非条件Logistic回归分析显示,存在母亲孕期用药史、母亲职业有害暴露、母亲不良妊娠史、父亲饮酒年限﹥10年和住房装修史者,其OR值分别为2.853(P=0.032)、3.477(P=0.000)、10.644(P=0.034)、5.853(P=0.005)和5.896(P=0.015)。[结论]母亲孕期用药史、母亲职业有害暴露、母亲不良妊娠史、父亲饮酒年限﹥10年和住房装修史是儿童青少年恶性肿瘤发病的高危因素。
[Objective] To investigate and analyze the risk factors of malignant tumor in 0-18-year-olds in Guangdong province and provide the direction and ideas for the prevention and treatment of malignant tumors in this population. [Methods] The cases of malignant neoplasms of 0-18 years old in Guangdong Province from December 2002 to May 2005 were collected. Univariate analysis with SPSS15.0 statistical software was performed by case-control method. Conditional logistic regression analysis. [Results] Multivariate non-conditional Logistic regression analysis showed that the ORs of maternal pregnancy history, mother’s occupational exposure, mother’s adverse pregnancy history, father’s drinking duration> 10 years and the history of housing decoration were 2.853 (P = 0.032 ), 3.477 (P = 0.000), 10.644 (P = 0.034), 5.853 (P = 0.005) and 5.896 (P = 0.015). [Conclusion] Maternal medication history during pregnancy, maternal exposure to occupational hazards, maternal adverse pregnancy history, father drinking years> 10 years and housing decoration history are risk factors for the onset of malignant tumors in children and adolescents.