为改善水难溶性药物布地奈德(BUD)经鼻给药的溶出和吸收,采用新型聚合物材料Soluplus为载体,以冻干技术制备了无定形固体分散体(或固体溶液)。鼻腔给药时给药体积少,限制了难溶性药物的吸收。BUD是类固醇皮质激素,几乎不溶于水,通常以混悬型鼻喷雾剂给药。本试验通过将药物-聚合物溶液冻干得到冻干粉,并表征 To improve the dissolution and absorption of nasal administration of budesonide (BUD), an amorphous solid dispersion (or solid solution) was prepared by lyophilization technique using a novel polymer material, Soluplus, as a carrier. Nasal administration when administered in small volumes, limiting the absorption of insoluble drugs. BUD is a steroid hormone that is almost insoluble in water and is usually given as a nasal spray. In this experiment, the drug-polymer solution is lyophilized to obtain lyophilized powder and characterized