The study on relationship between eco-geographic environment (EGE) and regional development (RD) is of theoretical and practical significance to promote the comprehensive study on nature and human factors and regional coordination development. Based on the evaluation index system and models of EGE and RD, Quadrant Analysis Method (QAM) and the Coordination Degree and Coordinated Development Degree Model (CDCDDM) were applied to studying the relationship between EGE and RD in Xinjiang in this paper. The results show that Xinjiang can be divided into four type regions according to the relationship between EGE and RD, namely high coordination region (HCR), overloading development region (ODR), low coordination region (LCR) and potential development region (PDR). Most areas of Xinjiang belong to LCR which can not bear a larger population and support large-scale economic development. HCR, ODR and PDR, which are mainly distributed in piedmont oases and take basin as unit, should be focused on in the development of Xinjiang. The EGE has great influence on RD, and there is serious contradiction between them. Relevant suggestions on development strategies were put forward according to the character of different type regions, and the key regions of macro-layout of RD in Xinjiang were pointed out.