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唐氏综合征(DS)是最常见的染色体疾病,其第21号染色体由一个三倍体构成。过氧化物歧化酶(SOD)是一个金属蛋白系列,广泛存在于哺乳动物的组织中,其基因位于第21号染色体长臂上。它能通过催化过氧化物成为氧及过氧化氢,保护细胞免受毒性氧衍生物的作用。有报道在DS患者红细胞内,SOD明显增加,DS受累的妊娠羊水中,比对照组有较高的酶活性,至今无DS受累妊娠母血中SOD水平报道。为证实在DS受累妊
Down Syndrome (DS) is the most common chromosomal disease and chromosome 21 consists of a triploid. Superoxide dismutase (SOD) is a metalloprotein family that is found extensively in mammalian tissues and whose gene is located on the long arm of chromosome 21. It acts as a catalyst for peroxides to become oxygen and hydrogen peroxide, protecting cells from toxic oxygen derivatives. It has been reported in DS patients erythrocytes, SOD increased significantly, DS involving amniotic fluid in pregnant women, compared with the control group has a high enzyme activity, so far no DS involved in pregnancy maternal serum SOD levels reported. To confirm pregnancy involvement in DS