本文报道了用七种手性相转移催化剂(其中三种未见文献报道)催化氯化苄或溴丁烷对α-异丙基对氯苯乙腈或α-异丙基苯乙腈的不对称烷基化反应.考察了反应时间、温度、催化剂浓度和溶剂的极性等因素对不对称反应的影响.不对称烷基化产物的最大e.e.值达41.5%,由比旋光度和带手性柱的气相色谱法测得. In this paper, we report the use of seven chiral phase transfer catalysts (three of which have not been reported in the literature) for the catalytic asymmetric alkylation of benzyl chloride or bromobutane to α-isopropyl p-chlorophenyl acetonitrile or α-isopropylphenylacetonitrile The effects of reaction time, temperature, catalyst concentration and solvent polarity on the asymmetric reaction were investigated.The maximum ee of the asymmetric alkylated product was 41.5%, which was determined by the specific rotation and the chiral column Gas chromatography measured.